br Baade PD Youlden DR Andersson TM Youl PH Walpole
7. Baade PD, Youlden DR, Andersson TM, Youl PH, Walpole ET, Kimlin MG, et al. Temporal changes in loss of life expectancy due to cancer in Australia: Phosphatase Inhibitor Cocktail flexible parametric approach. Cancer Causes Control 2016; 27: 955-964.
9. Syriopoulou E, Bower H, Andersson TM, Lambert PC, Rutherford MJ. Estimating the impact of a cancer diagnosis on life expectancy by socio-economic group for a range of cancer types in England.
colon, breast, and testicular cancer patients: an analysis of US-SEER population-based data. Ann
11. Shrestha A, Martin C, Burton M, Walters S, Collins K, Wyld L. Quality of life versus length of life considerations in cancer patients: A systematic literature review. Psychooncology 2019. doi: 10.1002/pon.5054.
14. Ederer F, Axtell LM, Cutler SJ. The relative survival: a statistical methodology. Natl Cancer Inst
18. Surveillance Research Program, National Cancer Institute SEER*Stat software (seer.cancer.gov/seerstat) version 8.3.5
19. Hakama M, Hakulinen T. Estimating the expectation of life in cancer survival studies with incomplete follow-up information. J Chron Dis 1977; 30: 585 –587.
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This article does not contain any studies with human or animal subjects
Conflict of Interest
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Changes in total thyroidectomy versus thyroid lobectomy for papillary thyroid cancer during the past 15 years
Benjamin C. James, MD, MSa,*, Lava Timsina, PhDb, Ryan Graham, BSc, Peter Angelos, MD, PhD, FACSd, David A. Haggstrom, MD, MASe,f,g
a Section of Endocrine Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
b Indiana University School of Medicine, Department of Surgery, Indianapolis
c Indiana University School of Medicine, Indianapolis
d Section of Endocrine Surgery, Department of Surgery, University of Chicago, IL
e Indiana University School of Medicine, Department of Medicine, Division of General Internal Medicine and Geriatrics, Indianapolis
f Center for Health Information and Communication, US Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service, Richard L. Roudebush VA Medical Center, Indianapolis, IN
g Regenstrief Institute, Inc, Indianapolis, IN
Background: The incidence of papillary thyroid cancer has increased substantially during the past 15 years, which is likely related to an increased detection of small, nonlethal cancers. Studies have shown that patients may have a similar prognosis when undergoing less aggressive surgical intervention, such as thyroid lobectomy. The objective of lungs study is to determine whether surgical treatment patterns for papillary thyroid cancer have changed during the past 15 years.
Methods: We performed a retrospective cohort study evaluating changes in the incidence and proportion of total thyroidectomy versus thyroid lobectomy for histologically confirmed papillary thyroid cancers, using the National Cancer Institute Surveillance, Epidemiology, and End Results cancer registries be-tween 2000 and 2014.
Results: During the study period, 44,537 patients underwent surgical treatment for papillary thyroid cancer, of which 77% were female and 81.3% were white. The incidence of papillary thyroid cancer more than doubled: from 6.2 (5.9e6.5) to 13.0 (12.5e13.4) per 100,000. The proportion of total thyroidectomy among all papillary cases increased from 78.16% in 2000 to 85.67% in 2014, and the proportion of thyroid lobectomy dropped from 16.62% to 11.41%. When stratified by tumor size, we observed a sustained and increasing gap in the proportions of total thyroidectomy and thyroid lobectomy.
Conclusion: The incidence of total thyroidectomy has not decreased despite recommendations encour-aging consideration of lobectomy for patients with small papillary thyroid cancers. Although these findings could be attributed to the lag between scientific evidence and clinical practice, further work is warranted to explore any additional patient and provider factors that may explain this lack of change.
Throughout the past several decades, the incidence of thyroid cancer has increased by 3% annually, and thyroid cancer is close to being the third most-common cancer type in women.1,2 The ma-jority of this increase has occurred in small papillary thyroid
* Reprint requests: Benjamin C. James, MD, MS, Chief, Section of Endocrine Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Assistant Professor of Surgery, Harvard Medical School, 185 Pilgrim Road, Palmer 605, Boston, MA 02115.
E-mail address: [email protected] (B.C. James).